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Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation ( vasodilation ) of the intimal cushions of the helicine arteries.Find patient medical information for Viagra oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

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Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum.Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects.

The patent on Revatio (indicated for pulmonary arterial hypertension rather than erectile dysfunction) expired in late 2012.

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Caution is advised in those who have cardiovascular disease.Viagra User Reviews Now you can gain knowledge and insight about a drug treatment with Patient Discussions.It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease ).

Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).Psychostimulants (e.g., amphetamines, cocaine, methylphenidate ).Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.

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